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MEK Inhibitor Mechanism of Action, Side Effects, and Uses Professional

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How Do Antineoplastic Egfr Inhibitors Work?

Antineoplastic epidermal growth factor receptor (EGFR) inhibitors are a class of drugs used to treat hormone receptor-positive breast cancer (breast cancer that depends on hormones such as estrogen to grow), medullary thyroid cancer, advanced head and neck cancer, metastatic colorectal cancer, non-small cell lung cancer, and pancreatic cancer.

EGFR inhibitors are anti-cancer medications that block the activity of a protein called EGFR. EGFR is found on the surface of some normal cells and is involved in cell growth, also found at high levels on some types of cancer cells, which causes these cells to grow and divide. Blocking EGFR helps in preventing unregulated cell division, thus preventing the growth, and spread of cancer cells.

EGFR inhibitors can be classified into the following:

Tyrosine kinase inhibitors: targets the intracellular domain in EGFR and stops the activity of the EGFR.

Monoclonal antibodies: targets the extracellular ligand-binding domain of EGFR and prevents cell division.

EGFR inhibitors are administered via intravenous (into a vein) and oral routes.

EGFR inhibitors work in the following ways:

They belong to a class of medications called “tyrosine kinase inhibitors” that work by slowing down or stopping the growth of cancer cells.

They work by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

They block the activity of a protein called "EGFR" and thus prevent unregulated cell division.